Acute Myeloid Leukemia With Inv16 Or Variant

AML with inv(16) is characterized by abnormal bone marrow eosinophilic precursors. Most will be associated with a pericentric inversion of chromosome 16.31 Less commonly, patients will have a translocation between two homologous of chromosome 16.31 CD2 is often aberrantly expressed.17 Associated clinical features include a good prognosis with high-dose cytara-bine, hyperleukocytosis, young age at diagnosis, and an increased risk for CNS involvement.1732-34 Extramedullary sites of disease, including cervicoton-sillar involvement and generalized lymphadenopathy, are particularly common, with a 33% incidence.17 An increased incidence of acute pulmonary syndrome (pulmonary infiltrates, hypoxia, fever, and impending respiratory failure) has also been reported in patients with AML and inv(16) (54%) versus patients with the same diagnosis but without inv(16) (9%).35

0 0

Post a comment