Adult Softtissue Sarcoma

Small series of metastatic soft-tissue sarcoma patients treated with high-dose chemotherapy have been reported. When used as initial61 or salvage therapy for refractory disease,62 high-dose chemotherapy has not produced a clear survival benefit. However, results appeared improved when used as consolidation after induction conventional-dose chemotherapy, particularly for patients transplanted in CR. Blay et al.63 treated 30 patients with responsive metastatic disease with high-dose ifosfamide, etoposide, and cisplatin. At a median follow-up of 94 months, the EFS and OS rates were 21 and 23%, respectively. Those patients in CR before high-dose chemotherapy had a better outcome than those in PR (5-year OS 75% vs 5%).

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