Advancedstage Disease

Patients with advanced follicular NHL are characterized by an indolent clinical course with a median survival of 6-10 years.16,17 Nevertheless, early intervention with treatment in patients with asymptomatic, nonbulky disease has not been associated with a prolongation of survival.1819 As a result, a watch-and-wait approach has been routinely recommended until treatment is clinically indicated on the basis of disease-related symptoms, massive or progressive lymphadenopathy or hepatosplenomegaly, potential organ compromise, or bone marrow involvement resulting in peripheral blood cytopenias.

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