Alkylating Agents

Thousands of variants of the basic chemical structure of nitrogen mustard have been developed over the years, but few have matched the success and utility of the original compound. These variants include some of the oldest, yet most valuable of all antineoplastic drugs. Five basic types of alkylating agents are currently in use.

■ Nitrogen mustard derivatives (mechlorethamine, cyclophosphamide, ifosfamide, melphalan, chlo-rambucil)

■ Ethylenimines (triethylenemelanime, thiotepa, altremaine)

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