Alternative Donor Sct Mud transplants

Using the NMDP, around 70% of Caucasian patients are likely to find an HLA-matched donor; for other ethnic groups the chances are much lower. Retrospective analysis of the NMDP data reported a 2-year survival of 29% for 31 patients with SAA.49 Better results were published from the Milwaukee group and the Fred Hutchinson Cancer Center Group, with 2-year survivals of 58% and 67%, respectively, using a more intensive conditioning regimen.46 50 MUD transplants as first-line therapy remain experimental, and are associated with high morbidity and mortality. Guidelines from a group of experts suggest that it be reserved for patients who have failed two courses of immunosup-pressive therapy.51

Age of patient _I_

> 40 years
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