Androgens

Androgens have been beneficial for the treatment of MMM-associated anemia. Various androgen formulations have been used in MMM patients, including nan-drolone,29 oxymetholone, and danazol.3031 Doses of danazol in the range of 600-800 mg/day led to responses in four out of seven patients (treated from 3 to 6 months) with MMM anemia in a report by Cervantes et al.30 In this study, responders had either previously been splenectomized, or had only modest splenomegaly. In addition, it has been suggested that MMM patients with karyotypic abnormalities are less likely to respond to palliative androgen therapy.29

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