Antithrombotic therapy

Low-dose aspirin, 80-100 mg daily, seems reasonable to recommend, in addition to cytoreduction, for patients who have a prior history of thrombosis or cardiovascular disease.9 In addition, aspirin is effective for the treatment of erythromelalgia and other microvas-cular, neurologic, and ocular disturbances.

In patients with PV who continue to have thrombotic or vascular symptoms, despite aspirin and good control of the hematocrit and platelet count with phlebotomy and myelosuppression, clopidogrel 75 mg daily or ticlopi-dine 250 mg orally twice daily should be considered.14

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