Autologous Transplantation

Autografting using Ph-negative stem cells harvested during recovery from induction chemotherapy may result in short-term cytogenetic remission and prolong survival modestly.72 73 However, Ph-positive hematopoiesis generally recurs quickly.

Several ongoing studies collect mobilized stem cells from patients who are not candidates for allogeneic transplantation and who achieve cytogenetic remissions with imatinib. When patients progress, autotransplantation is carried out. Such studies require sufficient accrual and follow-up to render meaningful results.74

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