Bone Marrow Biology

In older adults, AML is more likely to arise from a proximal bone marrow stem cell disorder,16 such as myelodys-plastic syndrome (MDS),17 and with leukemia-specific abnormalities in more than one hematopoietic cell lineage.18 This may explain the different disease behavior in this group, as well as prolonged neutropenia following chemotherapy.6 Older adults with AML also are more likely to have reduced proliferative capacities in normal hematopoietic stem cells,19 which also may affect blood count recovery following intensive chemotherapy.

0 0

Post a comment