Burkitts Lymphoma

BL is a rare tumor of mature B cells, thought to be of germinal center origin. Clinically, it is a highly aggressive disease, with frequent extranodal presentation, which may present as an acute leukemia. It is composed of monomorphic medium-sized B cells with numerous mitotic figures and basophilic cytoplasm. Single translocations involving the c-myc oncogene are always present in this disease, and may help to distinguish it from other aggressive B-cell lymphomas. Variant cases of BL, designated as atypical BL, Burkitt-like lymphoma, and BL with plasmacytoid differentiation are also recognized.

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