Cd20 A Target For Bcell Malignancies Including

CD20 is a 297-amino-acid glycoprotein that participates in B-cell activity and regulation of B-cell growth.29 It has two transmembrane domains, so that both the carboxyl and amino termini are present on the cytosolic surface of the membrane. Only a small loop of 44 amino acid residues is extracellular, so CD20 is tightly held by the cell membrane and not shed. CD20 is expressed on >95% of B-cell non Hodgkin's lymphoma (NHL), but not on stem cells or plasma cells.30 Its expression is lower in CLL, but higher in HCL.631

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