Chronic Myeloid Leukemia

CML develops with an insidious onset of symptoms and signs, which may include fatigue, anemia, splenomegaly, and leukocytosis marked by an increase in neutrophils, eosinophils, and basophils. The median age of onset is 50 years12 the peak incidence occurs between 50 and 60 years.12 The frequency increases with age. CML occurs equally in males and females.1

There are three phases of the disease: the first, a chronic phase, lasts 30-40 months; the second is a transitional phase called the accelerated phase; and the terminal blast or acute ("blast crisis") phase, in which the disease resembles acute leukemia. In some patients, there is no transitional phase, and the disease transforms abruptly into an acute phase.

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