Chronic Myelomonocytic Leukemia

CMML has features both of myelodysplasia and myeloproliferation. In the WHO classification it has migrated from the MDS catergory into the MPD/MDS disorders. To differentiate CMML from atypical CML, evaluation of the proportion of granulocytic precursors and the blood film to identify anormal mono-cytes are useful. The bone marrow is hypercellular and displays varying degrees of dysplasia and a monocytic infiltrate. Cytogenetic abnormalities are common (20-50%) but again none are specifically associated with CMML. Those patients with abnormal karyotypes are more likely to have advanced disease and to transform to acute leukemia.75

Monosomy 7 is common, as are +8, der(12p) presenting as a terminal deletion or translocation, -Y.75 Abnormalities of chromosome 5 (-5, 5q-, t(5;12) (q31p13)) are less common in CMML than in myelodysplasia.

0 0

Post a comment