Classification Of Hodgkins Lymphoma

The classification of HL has undergone substantial changes over the last decade, reflecting an improved understanding of the underlying biology of this neo-plasm.14 In 1966, the Rye conference modified the earlier Lukes and Butler classification system to produce four histologic subtypes of HD: Lymphocyte predominance, nodular sclerosis, mixed cellularity, and lymphocyte depletion.1516 This scheme was widely used for the next 30 years. The Rye classification was popular among pathologists for its simplicity and ease of use and was equally popular among clinicians because the individual subtypes were associated with prognostic differences when treated with then-current therapy.17

Table 71.1

Rye (1966)

Classification of Hodgkin's Lymphoma

REAL (1996)

WHO (2001)

Lymphocyte Lymphocyte Nodular lymphocyte predominance predominance predominance

Table 71.1

Lymphocyte Lymphocyte Nodular lymphocyte predominance predominance predominance

Nodular sclerosis

Classical Hodgkin's

Classical Hodgkin

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