Clinical Evaluation

The diagnosis of myeloma may not be obvious even in a "typical" case, as the presenting symptoms are not specific. Increasingly, patients are referred for evaluation after seeking medical attention for unexplained anemia, neuropathy, or renal failure. Incidental finding of a monoclonal serum protein is also becoming more frequent. A comprehensive evaluation of patients suspicious for a diagnosis of myeloma starts with thorough history and physical examination. The clinical findings help to direct further investigations for the precise diagnosis and quantification of the extent of disease.

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