Clinical Testing Of Rituximab In Clinical Hcl Trials

Several case reports treating HCL with rituximab have appeared since 1999.37-41 Four small studies have been reported in which rituximab was administered to patients with HCL (Table 33.1). Hagberg and Lundholm reported 11 classic HCL patients treated with rituximab at 375/m2/week X 4.42 Three patients were newly diagnosed and eight were relapsed. All eight relapsed patients had received one to three courses of cladribine, and seven out of eight of these patients also had received one to two courses of interferon. Of the 11 patients, 7 had cytopenias as defined by hemoglobin, granulocytes,



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