Cml Treated With Hydroxyurea Or Busulfan

A large study of patients treated mostly with hydrox-yurea was the basis for the first widely recognized prognostic scoring system. Sokal et al. performed a multiple regression analysis of 625 chronic-phase patients aged 5-45 years and identified age, spleen size, hematocrit, platelet count, and the percentage of circulating blast cells as significant prognostic factors.14 The "Sokal" scoring system devised by this analysis classifies patients into risk categories that predict survival in patients treated with hydroxyurea.

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