Coexpression Of Cd38 On Leukemic B Lymphocytes

It has been observed that CLL patients whose leukemic lymphocytes do not coexpress CD38 have a better prognosis than those who are CD38 positive.4 Thus, it would seem logical to include CD38 positive patients (similar to VH-unmutated patients) among those in whom early intervention will be appropriate. This recommendation also appears reasonable, but there is a lack of agreement as to whether 30% or greater posi-tivity should be considered CD38 positive, or the threshold should be set at 13%. As in the case of VH mutations, we believe that defining when CD38 is called positive will be resolved soon, but until that happens, in our clinical practice, we do not make therapeutic decisions on that basis alone.

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