Comparisons Of Allo Sct Versus Auto Sct Intermediateand Highgrade

Table 65.6 shows a number of publications comparing alio SCT and auto SCT.7<10<24<30-34 Among the earliest reports were small series by Milpied and colleagues7 and Bureo and coworkers.32 Chopra et al.30 communicated one of the first matched case-control studies. The way they reported their data enabled them to evaluate various NHL subtypes. For both lymphoblastic lymphoma and intermediate- and high-grade NHL, the benefit of a reduced treatment-related mortality in auto SCT was offset by a higher relapse rate, i.e., allo SCT and auto SCT results were comparable. Subsequently, Peniket and the EBMTR24 retrospectively analyzed data from 1982 to 1998, in which they compared 1185 allogeneic transplants (as the first transplant) for lymphoma with 14,687 autologous procedures. Patients receiving allogeneic transplants were subdivided according to histology: low-grade NHL (231 patients); intermediate-grade NHL (147 patients); high-grade NHL (255 patients); lymphoblastic NHL (314 patients); Burkitt's lymphoma (71 patients); and Hodgkin's disease (167 patients). Actuarial overall survival at 4 years from transplantation was as follows: low-grade NHL 51.1%; intermediate-grade NHL 38.3%; high-grade NHL 41.2%;

| Table 65.7 Comparative analyses detailing outcome of myeloablative transplantation for low-grade NHL

No. of Nonrelapse Relapse or

| Table 65.7 Comparative analyses detailing outcome of myeloablative transplantation for low-grade NHL

No. of Nonrelapse Relapse or

References

Type

patients

mortality

PFS/EFS

0 0

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