Complications And Longterm Prognosis

In general, patients successfully treated with immunosuppression have an excellent prognosis, while nonre-sponders who cannot undergo stem cell transplantation have a poor survival. In recent years, the survival of chronically pancytopenic patients improved, likely due to advances in supportive care. Conversion of severe AA into moderate disease appears to be sufficient to significantly improve the long-term prognosis. The most common complications of AA include relapse and evolution of clonal disease. These complications occur in patients treated with immunosuppression. Recipients of allogeneic grafts show a different set of long-term com plications, including cataracts, thyroid disorders, and secondary cancers.100

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