Conclusions

The results of the ECOG 2993/MRC UKALL XII may ultimately define a role for autologous transplant in the management of adult ALL. At present, there is no clear group for which it should be considered a standard of care. Available data recommend allogeneic transplant in CR1 for all patients with ALL, though the data seem to be more robust among high risk patients. Outside clinical trials, autologous transplantation should be reserved for patients with poor prognostic factors in first remission who are not candidates for allogeneic SCT, or patients in second and subsequent remission.

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