Conclusions

Second malignancies have clearly evolved to be important causes of mortality in patients with curable lymphomas. As cure rates increase, and the cohort of patients treated with aggressive autologous transplantation and novel radioimmunotherapy approaches grows, it is anticipated that the incidence of second cancers will increase significantly. Perhaps most concerning is the lack of an apparent plateau in the incidence curve, even 20-30 years after diagnosis of lymphoma.53 For this reason, we feel it is critical that patients cured of lymphoma remain under care of medical and radiation oncologists attuned to these

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