Corticosteroids, which are part of the treatment of systemic NHL, have a role in the treatment of PCNSL, by reducing tumor-associated edema and causing lysis of malignant lymphocytes. Although initial responses may be as high as 40%, complete and durable responses are rare.28 Neither the specific type nor the optimal dose of corticosteroids has been established. Occasionally, the clinical and radiographic features are highly suggestive of PCNSL, and the tumor has regressed following corticosteroids, making tissue confirmation impossible. The initial response to corticosteroids appears to predict for outcome.29 Those patients with an excellent clinical and radiographic response following corticosteroids alone have a better long-term outcome than nonresponders.

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