Cytogenetic Abnormalities In Myeloma

Chromosome studies in multiple myeloma have become an important part of the management of myeloma patients. Early investigations were based on conventional karyotype analysis, with the detection of recurrent abnormalities, such as monosomy 13 and t(11;14). In recent years, developments in molecular cytogenetics ranging from metaphase and interphase fluorescent in situ hybridization (FISH) to multicolor spectral karyotyping (M-FISH) and comparative genomic hybridization (CGH) have greatly increased the range and number of detectable cytogenetic abnormalities (Figure 81.6). These techniques have overcome some limitations of conventional cytogenetics (CC) in myeloma, including (1) low mitotic index of myeloma cells; (2) multiple complex chromosomal abnormalities of myeloma complicating the identification of specific chromosomes; and (3) telomeric locations of translocational breakpoints and deletional sites, especially in 14q23.

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