Cytokine Mobilized Pbsc Versus Bone Marrow

In the setting of AA, there are no randomized control trials that have studied the benefit or disadvantages of one over the other source of stem cells. As with other allogeneic SCT, cytokine mobilized PBSC transplants are associated with faster engraftment, yet it is unclear if this translates to a superior outcome. Marsh et al. report that in personal communications the retrospective analysis of both European Blood and Marrow Transplant Group and the International Blood and Marrow Transplant Registry have shown significantly worse survival with PBSC versus bone marrow transplants (60% vs. 75%).47 In the setting of transplanting patients with SAA who have received multiple transfusions prior to their transplant, it has been reported that the use of PBSC improves the outcome.48

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