Definition And Use Of Prognostic Factors

Prognostic factors are variables measured in individuals that offer a partial explanation of the heterogeneity observed in the outcome of a given disease.5 Prognostic factors may be used to predict the outcome of Hodgkin's lymphoma on a population (or a group of patients) basis, but not for individual patients.6 Prognostic factors can be used to define risk groups, thus playing a role in treatment selection. In the setting of a clinical trial, they can be used in the definition of eligibility criteria and for stratification before randomization. In the analysis of a trial's results, prognostic factors may allow adjustments to improve the value of statistical comparisons made. However, the use of prognostic factors will never justify the comparison of treatments described by nonrandomized studies.78

0 0

Post a comment