Extramedullary plasmacytoma is diagnosed on the basis of finding a monoclonal plasma cell tumor in an extramedullary site, in the absence of multiple myeloma in the bone marrow and on radiographic tests, without protein spikes using appropriate studies of blood and urine (Table 84.2). Poorly differentiated neoplasms and lymphoma may be difficult to differentiate from plas-macytomas. In this situation, immunohistochemistry and flow cytometry are helpful in making the diagnosis. There is a higher incidence of IgA M-protein subtype in extramedullary plasmacytoma.

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