Drugresistance Genes

The expression of genes that mediate drug resistance occurs with increased frequency in this age cohort.20 MDR1, the so-called p-glycoprotein (gp170) chemotherapy efflux pump, was found in 71% of leukemic blasts in subjects in a Southwest Oncology Group study

Table 5.1 Comparison of older and younger adults with AML

Older AML Younger AML Characteristic patientsa patientsa

Population incidence13

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