Effect Of Age On Outcome

Long-term survival for patients with AA undergoing an HLA-identical sibling transplant varies from 75% to 90%.38-41 In most studies, patient age has a significant bearing on the outcome following an allogeneic stem cell transplant. There is some controversy as to the upper age limit at which an HLA-identical related allo-geneic SCT would be offered as an initial therapy, with most recommendations putting the upper age limit as 40 years42; the study by Bacigalupo et al. showed that the outcomes were significantly worse for those older than 30 years.41 Following failure of standard immuno-suppressive therapy this option could be offered to all patients who have a donor and have no other contraindication to undergo an allogeneic SCT.

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