Effect Of Ipss Score On Outcome

IPSS scores have been shown to have a bearing on the outcome following an allogeneic SCT.78 In the more recent publication by Deeg et al.,8 the 3-year RFS was 80% for patients with low-risk MDS (IPSS score 0), which progressively decreased with increasing scores to 29% among patients with an IPSS score higher than 2 (Figure 42.1). Earlier studies had shown a similar correlation with cytogenetic risk groups and posttrans-plant outcomes in patients with MDS. Nevill et al.18 showed a 7-year event-free survival of 51%, 40%, and 6% in the good-, intermediate-, and poor-risk cytoge-netic risk groups, respectively. Since the IPSS score includes additional parameters of percentage of blasts in the bone marrow and number of cytopenias at diagnosis,

Years (com Transplantation

Figure 42.1 Impact of IPSS score on outcome. The + indicates censored patient; in 7 patients, an IPSS score could not be assigned. (a) Relapse-free survival. (b) CI of relapse. (Reprinted from Ref. 8, used with permission.)

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