Electron Microscopy

By electron microscopy inspection, hairy cells have circumferential cytoplasmic projections and a few blunt microvilli.66 Ribosomal lamella complexes, cylindrical cytoplasmic inclusions composed of a central hollow space surrounded by the multiple parallel lamellae with ribosomal-like granules in the inter-lamellar space, are discovered in 50% of patients with HCL by electron microscopy.67 However, such complexes are not pathognomonic for HCL, and have been described in other lymphoproliferative disorders.68

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