Epidemiology

Classified as a distinct subtype of HL by the WHO classification,1 LP HL is a monoclonal B-cell neoplasm characterized by a nodular polymorphic infiltrate composed of small lymphocytes, histiocytes, and large neoplastic cells, referred to as popcorn and L&H cells, that differ morphologically and immunohistochemi-cally from Reed-Sternberg cells. L&H cells usually have one large multilobated nucleus with limited cytoplasm. These cells, unlike Hodgkin's Reed-Sternberg cells, are frequently positive for CD20 and CD 7 9a, while negative for CD30 and CD15. Several series have also described unique clinical features for this subtype of HL.5-9 44 LP HL represents 3-5% of all HLs and typically afflicts 30- to 50-year-old males.4

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