Erythroleukemia can occasionally be familial.36-38 Signs or symptoms which occur more commonly with this subtype include synovitis, serositis, effusions, bone pain, and immunologic abnormalities.4,36,39 Rheumatologic symptoms tend to respond to antiinflammatory agents.36 39 Specific immunologic abnormalities include hypergammaglobulinemia, a positive Coombs test, a positive antinuclear antibody test, and an elevated rheumatoid factor titer.36 39 Cytogenetics demonstrate aneuploidy in almost two-thirds of patients.4,40,41

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