Essential Thrombocythemia Et

By far the most common cause of thrombocytosis in general medical practice is a reactive or secondary process. This is related to acute or occult bleeding, infection, or malignant diseases. Thus, a careful history, physical examination, and appropriate laboratory studies should establish the cause of secondary thrombocytosis in the majority of cases.

Thrombocytosis may be associated with the myelodysplastic 5q- syndrome, which is characterized by deletion of the long arm of chromosome 5 (see Chapter X). In addition to thrombocytosis, these

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