Ethnic Differences In Hla Allele And Haplotype Frequencies

Certain alleles and allele combinations (haplotypes) have very different frequencies in different ethnic or racial groups.58 65-67 Further, a greater complexity due to the variety of alleles and haplotypes is also seen in some groups. The probability of finding an HLA-matched unrelated donor is affected both by this complexity and by the number of individuals of that group represented in the various registries.66,68-70 These considerations are the basis for unrelated donor registry recruitment efforts among minority groups.

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