Etiology Of Multiple Myeloma

Although the etiology of MM remains unknown, several environmental, occupational, and genetic factors have been associated with increased risk of developing MM. Although these risk factors are discussed disjoint-edly, it must be recognized that many factors contribute to the risk of each single case. In the search for factors that cause cancer, epidemiologists have used cohort and case-control studies. A defined population's "cohort" exposed to factors suspected of increasing the incidence of a cancer and a control "matched" group are followed for incidence of cancer. These factors are then investigated further if high incidence of a cancer is seen. Case-control studies begin with a cluster of cancer cases that are followed by investigating the exposure to various agents. Case-control studies are conducted quickly with fewer subjects. However, they are biased by selection and the ability of subjects to remember exposures.

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