Evaluation Of Prognosis

MMM is a disease with a wide degree of prognostic variability, with most patients eventually expiring from their disease in the absence of leukemic transformation (LT). Several prognostic factors have been examined, with the most useful being the Lille criteria for MMM,13 which include the presence or absence of anemia (hemoglobin <10 g/dL) or extremes of leukocyte count (<4 or >30 X 109/L). The Lille criteria modeled median survival in MMM patient groups of 93, 26, and 13 months, respectively, based on the presence of 0, 1, or 2 abnormalities. Additional negative prognostic factors include increasing age,14 increased circulating myeloblasts at diagnosis,15 increased peripheral blood CD34+ cell count,16 and abnormal karyotypic analysis14 (especially trisomy 8 and deletions of the "p" arm of chromosome 12).

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