Evolution Of Clonal Disease

With the introduction of IS therapy, the survival of AA patients who are not treated with stem cell transplantation has improved significantly.9 With long-term systematic observation, evolution of AA to other hematologic diseases has been frequently recognized as a serious late complication. Historically, the development of PNH was considered the most common clonal complication of AA. Although the appearance of PNH clones is often already observed at first presentation of bone marrow failure,7071 manifest PNH develops in a much smaller but significant proportion of patients. MDS is another common clonal disease occurring in the context of AA.

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