With increasing recognition that cancer is a genetic disease, the genotype of lymphomas is assuming greater significance in their classification. For some entities such as follicular lymphoma, [t(14;18)], and mantle cell lymphoma, [t(11;14)], the genotype is indeed the defining property. However, genotyping is beyond the capability of most laboratories and, fortunately, the genotype finds expression as reproducible morphological and/or immunophenotypic features that allow confident and reproducible diagnoses.

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