Hairy Cell Leukemia Variant

HCLv is a rare clinicopathologic entity first described in 1980. Most patients with HCL reported from Japan also exhibit features similar to those of the HCLv.6970 Unlike HCL, HCLv is associated with prominent leukocytosis,

Table 30.2 Differential diagnosis of hairy-cell leukemia Hairy cell leukemia variant (HCLv)

Polyclonal hairy B-cell lymphoproliferative disorder (HBLD) Splenic marginal zone lymphoma (SMZL) Systemic mastocytosis (SM) Chronic lymphocytic leukemia (B-CLL)

Table 30.3 Differential diagnosis of hairy-cell leukemia Immunophenotype of B-cell chronic lymphoid leukemias

Antigen

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