Highdose Therapy For Highrisk Breast Cancer Phase II studies

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The use of high-dose therapy with, initially, BM and, later, Peripheral blood progenitor cell(s) (PBPC) rescue was first explored and reported by Peters et al.25 at Duke University and by Gianni et al.26 at Milan. Each reported results that appeared superior to outcomes after conventional-dose chemotherapy using similar patient selection criteria. Specifically, Peters et al. reported a 72% 5-year EFS in a prospective phase II trial of high-dose cyclophosphamide/cisplatin/BCNU in patients with 10 or more positive axillary nodes. These results have stood the scrutiny of time, with 61% EFS rate at 11-year follow-up.27 Gianni et al.26 used a sequential high-dose single-agent regimen in this patient population. At a median follow-up of 4 years, the observed EFS rate was 57%.

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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