History Of Acute Myelogenous Leukemia

Acute myelogenous leukemia (AML) is a clonal disorder of the bone marrow that is characterized by abnormal proliferation of immature myeloid cells and arrested stem cell differentiation.1 The history of AML dates back to the middle of the nineteenth century, when Virchow described the clinical disease as "the direct cause for the increase in the number of colorless particles in the blood."2 In 1868, Neumann related AML to changes in the bone marrow.2

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