Hla Alleles

The genes of the HLA complex include the most polymorphic human genes with known function. For class I and class II loci that may be considered for matching in transplantation, there are more than 1700 alleles described (Table 93.2) (http://www.ebi.ac.uk/imgt/ hla/index.html).54 Considering the number of loci present per haplotype and the number of alleles at each locus, there is the formal possibility of an incredibly large number of distinct HLA haplotypes (>9 X 109 for

Table 93.2

Polymorphism of HLA genes

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