Hla Structure And Function

The HLA class I19,20 and class II21,22 molecules were revealed by crystallographic studies to be similar in overall structure. The extracellular portion of both molecules is composed of four domains (Figure 93.3). A peptide binding structure formed by the two domains most distal to the cell membrane (a1, a2 of class I and a1, p1 of class II) sits atop two membrane proximal domains (a3 and p2M of class I and a2, p2 of class II). The intron/exon arrangement of the class I and class II HLA

Class [I Class I

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