Hlamatched Related Grafts

We recently reviewed results of the first 212 patients treated by our group of collaborators.18 Conditioning regimens consisted of 2 Gy TBI alone (n = 102), or 90 mg/m2 fludarabine plus 2 Gy TBI (n = 110). Patient diagnoses included multiple myeloma (n = 66), acute leukemias or myelodysplastic syndromes (n = 58), chronic leukemias (n = 43), lymphomas (n = 41), and other hematologic malignancies (n = 4). Median patient age was 55 (range 18-73) years. The declines in blood counts after HCT were generally modest. The incidences of grade II, III, and IV acute GvHD were 29, 10, and 5%, respectively. Chronic GvHD was seen in 65% of patients. With a median follow-up of 11.5 (3-42) months, overall survival and progression-free survival were 63 and 52%, respectively. Typically, remissions occurred over extended periods of time, and some patients achieved complete remissions beyond 1 year posttransplant.

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