Igh Switch Translocation

The most common structural chromosomal abnormality in myeloma is IgH switch translocation, involving the IgH gene locus on chromosome 14q32. Using interphase FISH, its incidence is 50% in MGUS, 60-75% in multiple myeloma, and more than 80% in plasma cell leukemia.35-38 There is a large array of non-immunoglobulin translocation partners, with the most common ones being 11q13, 4p16.3, 16q23, and 6q23. Cloning of the breakpoints of these genes has shown that they contain candidate oncogenes. As the oncogenes are translocated to der(14), they may be activated while under the control of IgH enhancers.

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