Immune Stimulation And Myeloma Chronic infections and eczema

Many medical conditions associated with chronic stimulation of the immune system, such as repeated infections, allergic conditions, or autoimmune disease, have been reported to increase the risk of MM. In a case-control study, past history was abstracted from medical records for leukemia, n = 299; non-Hodgkin's lymphoma (NHL), n = 100; and MM, n = 175 patients, and matched with 787 controls. Prior histories of eczema and musculoskeletal conditions were associated with higher risk for MM with no role identified for chronic antigenic stimulation in the etiology of leukemia or NHL.32 Another case-control study of 100 MM cases in whites showed no associations between MM and history of medical conditions that cause prolonged stimulation of the immune system, like chronic infections, autoimmune disorders, allergy-related disorders, or lymphoid tissue surgery.33

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