Immunophenotypic Assessment

Specific ALL phenotypes, such as T- or B-cell-lineage disease, cannot be distinguished by morphologic assessment. Immunophenotyping by flow cytometric analysis provides a rapid and accurate method to characterize distinct ALL subtypes. As distinguished in the World Health Organization Scheme, these consist of early precursor B-cell ALL, common B-cell ALL, precursor B-cell ALL, mature B-cell (Burkitt-type) ALL, precursor T-cell ALL, and T-cell ALL.41-43 Table 12.2 shows the specific lymphoid markers that are expressed with the various ALL subtypes. Further discussion of immunophenotyping for ALL is found in Chapter 11.

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