Immunophenotypic Profile

Flow cytometric immunophenotyping is a critical part of the diagnostic evaluation of HCL, and helps to distinguish it from other lymphoproliferative disorders.

Figure 30.2 (a) Bone marrow trephine biopsy showing hairy cells with spindle shape nuclei. (b) Bone marrow trephine biopsy stained for reticulin, demonstrating extensive fibrosis surrounding the individual hairy cells, typical for HCL
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