Infectious Complications

Significant neutropenia and monocytopenia predispose patients with HCL to infections from a wide variety of typical and opportunistic organisms.15 Infections with Mycobacterium kansasii, Pneumocystis carinii, aspergillus, histoplasma, cryptococcus, Listeria monocy-togene, and Toxoplasma gondii have been described.15-17 In addition to neutropenia and monocytopenia, the milieu making patients susceptible to infections includes T-cell dysfunction, decreased numbers of dendritic and antigen-presenting cells, as well as impaired interferon production by mononuclear cells.18-21

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